Publications

Publications:      

1.     A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Richard D. Bunker, Kalyaneswar Mandal, Ghader Bashiri, Jessica J. Chaston, Brad Pentelute, J. Shaun Lott, Stephen B. H. Kent*, Edward N. Baker*, Proc Natl Acad Sci USA, 112, 4310-5 (2015).

2.    Enhanced solvation of peptides attached to a ‘solid-phase’ resin: straightforward synthesis of the elastin sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val. B. Dang, B. Dhayalan, S.B.H. Kent, Organic Letters, 17, 3521-3 (2015).

3.    Efficient total chemical synthesis of 13C=18O isotopomers of human insulin for isotope-edited FTIR. B. Dhayalan, A. Fitzpatrick, K. Mandal, J. Whittaker, M. A. Weiss, A. Tokmakoff,*  S. B. H. Kent*, ChemBioChem, 17, 415-420 (2016).

4.    Spontaneous resolution of crystalline insulins from quasi-racemic solutions: Xray structure determination of isotope-labeled ester-insulin and human insulin. K. Mandal, B. Dhayalan, M. Avital-Shmilovici, A. Tokmakoff, S.B.H. Kent, ChemBioChem, 17, 421-425 (2016).

5.    A potent D-protein antagonist of VEGF-A is non-immunogenic, metabolically stable and longer-circulating in vivo. Maruti Uppalapati, Dong Jun Lee, Kalyaneswar Mandal, Hongyan Li, Les P. Miranda, Joshua Lowitz, John Kenney, Jarrett J. Adams, Dana Ault-Riché, Stephen B. H. Kent, Sachdev S. Sidhu, ACS Chemical Biology, 11, 1058-65 (2016).

6.    Elucidation of the covalent and tertiary structures of biologically active Ts3 toxin. Bobo Dang, Tomoya Kubota, Kalyaneswar Mandal, Ana M. Correa, Francisco Bezanilla, Stephen B. H. Kent, Angewandte Chemie Int. Ed., 55, 8639-42 (2016).

7.    Chemical synthesis and enzymatic properties of RNase A analogues designed to enhance second-step catalytic activity. David J. Boerema, Valentina A. Tereshko, JunLiang Zhang, Stephen B. H. Kent, Org. Biomol. Chem, 14, 8804 – 8814 (2016).

8.    Obviation of hydrogen fluoride in Boc chemistry solid phase peptide synthesis of peptide-αthioesters. Zachary P. Gates, Balamurugan Dhayalan, Stephen B.H. Kent, Chem. Comm., accepted for publication 2016.

9.    Scope & limitations of Fmoc chemistry SPPS-based approaches to the total synthesis of Insulin Lispro via ester insulin. Balamurugan Dhayalan, Kalyaneswar Mandal, Nischay Rege, Michael A. Weiss, Simon H. Eitel, Thomas Meier, Ralph O. Schoenleber, Stephen B.H. Kent, Chemistry – a European Journal, published on line 30th November 2016. DOI: 10.1002/chem.201605578

To see a full list of Kentlab papers, please click here.